Pressing the Pause Button on Aging Skin: OS-01 BODY’s 12-Week Clinically Validated Results
2 min read
DEC 20, 2023 - by tHE ONESKIN TEAM
December 20,2023
ONESKIN PRODUCTS
Pressing the Pause Button on Aging Skin: OS-01 BODY’s 12-Week Clinically Validated Results
2 min read
DEC 20, 2023 - by tHE ONESKIN TEAM
December 20,2023
ONESKIN PRODUCTS
As researchers, our roots are in the lab. However, we always want to bridge the gap between scientific data and real-world efficacy. That's why we conduct clinical studies – to move beyond lab-based results and dive into the tangible impact our topical supplements can have on your skin’s appearance and overall health. In our most recent 12-week clinical study, we tested the efficacy of OS-01 BODY, OneSkin’s daily moisturizer specifically designed for the skin below the neck and powered by the OS-01 peptide. During the study, we looked at a variety of factors including hydration, texture, systemic inflammation levels, and barrier function. Curious about what we found? As you’ll see here in a minute, the results were impressive.
As researchers, our roots are in the lab. However, we always want to bridge the gap between scientific data and real-world efficacy. That's why we conduct clinical studies – to move beyond lab-based results and dive into the tangible impact our topical supplements can have on your skin’s appearance and overall health. In our most recent 12-week clinical study, we tested the efficacy of OS-01 BODY, OneSkin’s daily moisturizer specifically designed for the skin below the neck and powered by the OS-01 peptide. During the study, we looked at a variety of factors including hydration, texture, systemic inflammation levels, and barrier function. Curious about what we found? As you’ll see here in a minute, the results were impressive.
01
Why our R&D process is different
One of our key differentiators is our cutting-edge research and development platform. Every product (including OS-01 BODY) starts in the lab. Each ingredient is tested individually on human skin samples, models, and cells, then tested again as a whole to ensure our products improve skin health and longevity at the cellular and molecular levels. Once we understand how they impact skin cells in a controlled setting, we move on to beta testing which allows us to see how our products work in everyday scenarios. Finally, we conduct clinical studies to validate our lab and real-world findings.
01
Why our R&D process is different
One of our key differentiators is our cutting-edge research and development platform. Every product (including OS-01 BODY) starts in the lab. Each ingredient is tested individually on human skin samples, models, and cells, then tested again as a whole to ensure our products improve skin health and longevity at the cellular and molecular levels. Once we understand how they impact skin cells in a controlled setting, we move on to beta testing which allows us to see how our products work in everyday scenarios. Finally, we conduct clinical studies to validate our lab and real-world findings.
02
Putting OS-01 BODY to the (clinical) test
Our 12-week double-blind clinical study included 52 participants, ages 60 to 90 years old. Half the group (Group A, n=27) used OS-01 BODY twice a day, while the other half (Group B, n=25) used a control moisturizer twice a day. Through specialized instruments, we measured hydration and barrier function – essentially how well the participants’ skin retained moisture and stayed protected against environmental stressors. But we didn’t just rely on quantitative data. We asked participants how they felt about their skin after using OS-01 BODY using a self-perception questionnaire. After all, it’s one thing to have data that proves a product works, it’s another for people using it to know it works. The study also monitored the biological age of participants using GlycanAge, a test that analyzes glycans (complex sugar molecules in the blood that change as you age) to tell us how old their bodies behaved before and after using OS-01 BODY. Additionally, we measured cytokine levels in their blood – critical biomarkers of systemic inflammation – to understand the surface-level effects of OS-01 BODY as well as deeper, whole-body impacts of our topical supplement.
02
Putting OS-01 BODY to the (clinical) test
Our 12-week double-blind clinical study included 52 participants, ages 60 to 90 years old. Half the group (Group A, n=27) used OS-01 BODY twice a day, while the other half (Group B, n=25) used a control moisturizer twice a day. Through specialized instruments, we measured hydration and barrier function – essentially how well the participants’ skin retained moisture and stayed protected against environmental stressors. But we didn’t just rely on quantitative data. We asked participants how they felt about their skin after using OS-01 BODY using a self-perception questionnaire. After all, it’s one thing to have data that proves a product works, it’s another for people using it to know it works. The study also monitored the biological age of participants using GlycanAge, a test that analyzes glycans (complex sugar molecules in the blood that change as you age) to tell us how old their bodies behaved before and after using OS-01 BODY. Additionally, we measured cytokine levels in their blood – critical biomarkers of systemic inflammation – to understand the surface-level effects of OS-01 BODY as well as deeper, whole-body impacts of our topical supplement.
03
The results: more hydration, less systemic inflammation
After 12 weeks of using OS-01 BODY, participants had significant improvements in hydration, skin barrier function, and inflammation levels as validated through our clinical instruments. Participants also reported enhancements in their skin’s general appearance and texture after 12 weeks. Some even noticed that their skin looked and felt better within 4 weeks. Here’s a breakdown of the data:
- Hydration: Up 38.34% on forearm skin and 38.38% on the upper arm*
- Skin barrier: Up 41.49% on forearm skin and 34.73% on the upper arm**
- Skin texture: 68% of participants noticed an improvement after four weeks and 70% of participants noticed an improvement after 12 weeks ***
- General appearance: 57% of participants noticed an improvement after 4 weeks and 70% of participants noticed an improvement after 12 weeks***
03
The results: more hydration, less systemic inflammation
After 12 weeks of using OS-01 BODY, participants had significant improvements in hydration, skin barrier function, and inflammation levels as validated through our clinical instruments. Participants also reported enhancements in their skin’s general appearance and texture after 12 weeks. Some even noticed that their skin looked and felt better within 4 weeks. Here’s a breakdown of the data:
- Hydration: Up 38.34% on forearm skin and 38.38% on the upper arm*
- Skin barrier: Up 41.49% on forearm skin and 34.73% on the upper arm**
- Skin texture: 68% of participants noticed an improvement after four weeks and 70% of participants noticed an improvement after 12 weeks ***
- General appearance: 57% of participants noticed an improvement after 4 weeks and 70% of participants noticed an improvement after 12 weeks***
04
Conclusion
We already understood the benefits of OS-01 BODY in the lab, but this study proves it can make substantial changes in real-life scenarios. From improved hydration for dry skin to a stronger skin barrier and lower inflammation biomarkers, OS-01 BODY does more than make your skin below the neck look better; it makes it healthier and more resilient against aging.
04
Conclusion
We already understood the benefits of OS-01 BODY in the lab, but this study proves it can make substantial changes in real-life scenarios. From improved hydration for dry skin to a stronger skin barrier and lower inflammation biomarkers, OS-01 BODY does more than make your skin below the neck look better; it makes it healthier and more resilient against aging.
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Key Takeaways:
- We test all our products using both scientific and clinical studies, so we have a comprehensive understanding of the results in the lab and real life
- During this clinical study, researchers observed improvements in skin hydration, skin barrier function, and cytokine levels in participants who used OS-01 BODY twice a day for 12 weeks
- Up to 72% of participants who used OS-01 BODY twice a day for 12 weeks noticed an improvement in the texture and overall appearance of their skin
- Participants’ biological age stayed the same in the group using OS-01 BODY but increased in the group using a regular moisturizer
Key Takeaways:
- We test all our products using both scientific and clinical studies, so we have a comprehensive understanding of the results in the lab and real life
- During this clinical study, researchers observed improvements in skin hydration, skin barrier function, and cytokine levels in participants who used OS-01 BODY twice a day for 12 weeks
- Up to 72% of participants who used OS-01 BODY twice a day for 12 weeks noticed an improvement in the texture and overall appearance of their skin
- Participants’ biological age stayed the same in the group using OS-01 BODY but increased in the group using a regular moisturizer
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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Peptides: the first piece of th...
Health Is The New Wealth
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