Pressing the Pause Button on Aging Skin: OS-01 BODY’s 12-Week Clinically Validated Results

2 min read

DEC 20, 2023 - by tHE ONESKIN TEAM
December 20,2023
ONESKIN PRODUCTS

Pressing the Pause Button on Aging Skin: OS-01 BODY’s 12-Week Clinically Validated Results

2 min read

DEC 20, 2023 - by tHE ONESKIN TEAM
December 20,2023
ONESKIN PRODUCTS
As researchers, our roots are in the lab. However, we always want to bridge the gap between scientific data and real-world efficacy. That's why we conduct clinical studies – to move beyond lab-based results and dive into the tangible impact our topical supplements can have on your skin’s appearance and overall health. In our most recent 12-week clinical study, we tested the efficacy of OS-01 BODY, OneSkin’s daily moisturizer specifically designed for the skin below the neck and powered by the OS-01 peptide. During the study, we looked at a variety of factors including hydration, texture, systemic inflammation levels, and barrier function. Curious about what we found? As you’ll see here in a minute, the results were impressive.
As researchers, our roots are in the lab. However, we always want to bridge the gap between scientific data and real-world efficacy. That's why we conduct clinical studies – to move beyond lab-based results and dive into the tangible impact our topical supplements can have on your skin’s appearance and overall health. In our most recent 12-week clinical study, we tested the efficacy of OS-01 BODY, OneSkin’s daily moisturizer specifically designed for the skin below the neck and powered by the OS-01 peptide. During the study, we looked at a variety of factors including hydration, texture, systemic inflammation levels, and barrier function. Curious about what we found? As you’ll see here in a minute, the results were impressive.
01

Why our R&D process is different

One of our key differentiators is our cutting-edge research and development platform. Every product (including OS-01 BODY) starts in the lab. Each ingredient is tested individually on human skin samples, models, and cells, then tested again as a whole to ensure our products improve skin health and longevity at the cellular and molecular levels. Once we understand how they impact skin cells in a controlled setting, we move on to beta testing which allows us to see how our products work in everyday scenarios. Finally, we conduct clinical studies to validate our lab and real-world findings.
01

Why our R&D process is different

One of our key differentiators is our cutting-edge research and development platform. Every product (including OS-01 BODY) starts in the lab. Each ingredient is tested individually on human skin samples, models, and cells, then tested again as a whole to ensure our products improve skin health and longevity at the cellular and molecular levels. Once we understand how they impact skin cells in a controlled setting, we move on to beta testing which allows us to see how our products work in everyday scenarios. Finally, we conduct clinical studies to validate our lab and real-world findings.
02

Putting OS-01 BODY to the (clinical) test

Our 12-week double-blind clinical study included 52 participants, ages 60 to 90 years old. Half the group (Group A, n=27) used OS-01 BODY twice a day, while the other half (Group B, n=25) used a control moisturizer twice a day. Through specialized instruments, we measured hydration and barrier function – essentially how well the participants’ skin retained moisture and stayed protected against environmental stressors. But we didn’t just rely on quantitative data. We asked participants how they felt about their skin after using OS-01 BODY using a self-perception questionnaire. After all, it’s one thing to have data that proves a product works, it’s another for people using it to know it works. The study also monitored the biological age of participants using GlycanAge, a test that analyzes glycans (complex sugar molecules in the blood that change as you age) to tell us how old their bodies behaved before and after using OS-01 BODY. Additionally, we measured cytokine levels in their blood – critical biomarkers of systemic inflammation – to understand the surface-level effects of OS-01 BODY as well as deeper, whole-body impacts of our topical supplement.
02

Putting OS-01 BODY to the (clinical) test

Our 12-week double-blind clinical study included 52 participants, ages 60 to 90 years old. Half the group (Group A, n=27) used OS-01 BODY twice a day, while the other half (Group B, n=25) used a control moisturizer twice a day. Through specialized instruments, we measured hydration and barrier function – essentially how well the participants’ skin retained moisture and stayed protected against environmental stressors. But we didn’t just rely on quantitative data. We asked participants how they felt about their skin after using OS-01 BODY using a self-perception questionnaire. After all, it’s one thing to have data that proves a product works, it’s another for people using it to know it works. The study also monitored the biological age of participants using GlycanAge, a test that analyzes glycans (complex sugar molecules in the blood that change as you age) to tell us how old their bodies behaved before and after using OS-01 BODY. Additionally, we measured cytokine levels in their blood – critical biomarkers of systemic inflammation – to understand the surface-level effects of OS-01 BODY as well as deeper, whole-body impacts of our topical supplement.
03

The results: more hydration, less systemic inflammation

After 12 weeks of using OS-01 BODY, participants had significant improvements in hydration, skin barrier function, and inflammation levels as validated through our clinical instruments. Participants also reported enhancements in their skin’s general appearance and texture after 12 weeks. Some even noticed that their skin looked and felt better within 4 weeks. Here’s a breakdown of the data:
  • Hydration: Up 38.34% on forearm skin and 38.38% on the upper arm*
  • Skin barrier: Up 41.49% on forearm skin and 34.73% on the upper arm**
  • Skin texture: 68% of participants noticed an improvement after four weeks and 70% of participants noticed an improvement after 12 weeks ***
  • General appearance: 57% of participants noticed an improvement after 4 weeks and 70% of participants noticed an improvement after 12 weeks***
*Measured by corneometer at 12 weeks vs baseline **Measured by tewameter at 12 weeks vs. baseline ***Self-perceptionBut here’s the really exciting part. The group that used OS-01 BODY had a significant reduction in IL-8 circulating cytokines compared to the baseline. Cytokines are indicators of inflammation in the body, and when those levels go down, so does systemic inflammation. While the changes weren’t significant compared to the control group, it’s a promising trend that confirms what we’ve suspected for some time – that stronger and healthier skin better protects your body from external factors, which may contribute to lower levels of inflammation throughout the body. And because this type of inflammation is a leading cause of age-related diseases (1), such as cardiovascular disease and dementia, using OS-01 BODY could be the first step to extending your health span. As for biological age, participants in the OS-01 BODY group didn’t show a change during the study, meaning their bodies didn't behave older or younger. However, researchers observed that the biological age of the group using the control moisturizer actually increased, which confirms that using OS-01 BODY can put the brakes on systemic aging.
03

The results: more hydration, less systemic inflammation

After 12 weeks of using OS-01 BODY, participants had significant improvements in hydration, skin barrier function, and inflammation levels as validated through our clinical instruments. Participants also reported enhancements in their skin’s general appearance and texture after 12 weeks. Some even noticed that their skin looked and felt better within 4 weeks. Here’s a breakdown of the data:
  • Hydration: Up 38.34% on forearm skin and 38.38% on the upper arm*
  • Skin barrier: Up 41.49% on forearm skin and 34.73% on the upper arm**
  • Skin texture: 68% of participants noticed an improvement after four weeks and 70% of participants noticed an improvement after 12 weeks ***
  • General appearance: 57% of participants noticed an improvement after 4 weeks and 70% of participants noticed an improvement after 12 weeks***
*Measured by corneometer at 12 weeks vs baseline **Measured by tewameter at 12 weeks vs. baseline ***Self-perceptionBut here’s the really exciting part. The group that used OS-01 BODY had a significant reduction in IL-8 circulating cytokines compared to the baseline. Cytokines are indicators of inflammation in the body, and when those levels go down, so does systemic inflammation. While the changes weren’t significant compared to the control group, it’s a promising trend that confirms what we’ve suspected for some time – that stronger and healthier skin better protects your body from external factors, which may contribute to lower levels of inflammation throughout the body. And because this type of inflammation is a leading cause of age-related diseases (1), such as cardiovascular disease and dementia, using OS-01 BODY could be the first step to extending your health span. As for biological age, participants in the OS-01 BODY group didn’t show a change during the study, meaning their bodies didn't behave older or younger. However, researchers observed that the biological age of the group using the control moisturizer actually increased, which confirms that using OS-01 BODY can put the brakes on systemic aging.
04

Conclusion

We already understood the benefits of OS-01 BODY in the lab, but this study proves it can make substantial changes in real-life scenarios. From improved hydration for dry skin to a stronger skin barrier and lower inflammation biomarkers, OS-01 BODY does more than make your skin below the neck look better; it makes it healthier and more resilient against aging.
04

Conclusion

We already understood the benefits of OS-01 BODY in the lab, but this study proves it can make substantial changes in real-life scenarios. From improved hydration for dry skin to a stronger skin barrier and lower inflammation biomarkers, OS-01 BODY does more than make your skin below the neck look better; it makes it healthier and more resilient against aging.

Related Products

Related Products

Key Takeaways:
  • We test all our products using both scientific and clinical studies, so we have a comprehensive understanding of the results in the lab and real life
  • During this clinical study, researchers observed improvements in skin hydration, skin barrier function, and cytokine levels in participants who used OS-01 BODY twice a day for 12 weeks
  • Up to 72% of participants who used OS-01 BODY twice a day for 12 weeks noticed an improvement in the texture and overall appearance of their skin
  • Participants’ biological age stayed the same in the group using OS-01 BODY but increased in the group using a regular moisturizer
Key Takeaways:
  • We test all our products using both scientific and clinical studies, so we have a comprehensive understanding of the results in the lab and real life
  • During this clinical study, researchers observed improvements in skin hydration, skin barrier function, and cytokine levels in participants who used OS-01 BODY twice a day for 12 weeks
  • Up to 72% of participants who used OS-01 BODY twice a day for 12 weeks noticed an improvement in the texture and overall appearance of their skin
  • Participants’ biological age stayed the same in the group using OS-01 BODY but increased in the group using a regular moisturizer
References
References

Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

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The Proof is in the Peptide: 12-Week Clinical Stud...
Why Is My Neck Aging So Fast?
6 Factors That Contribute to Slow Skin Healing
6 Tips and Tricks for a Youthful Neck
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Addressing the Need for Indoor Sun Protection
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The Science of Sunburns: How to Treat and Prevent ...
Get to Know OneSkin’s Topical Supplements:
OS-01 F...
Pollution
Can Air Quality Affect Skin? Exploring the Impact ...
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Understanding the Relationship Between Sleep and U...
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Exploring the Effects of Quality Sleep on Your Ski...
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How to Improve Gut Microbiome
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Exploring Caloric Restriction and Its Effects on A...
woman stretching in bed
What’s the Connection Between Quality Sleep and Lo...
Healthy foods
Unlocking the Skin Benefits of Intermittent Fastin...
woman exercising
Why Exercise is a Game-Changer for Longevity
The Microbiome Diet and Its Effects on Skin
The Microbiome Diet and Its Effects on Skin
cold water
Cold Exposure: Hype or Longevity Boosting?
healthy foods
Eat Better, Live Longer: Top Foods for Longevity
How Environmental Stressors Affect Skin
How to Protect Your Skin from Everyday Environment...
How Does Sunscreen Work? How Long Does it Last?
How Does Sunscreen Work? How Long Does it Last?
OS-01 BODY
Pressing the Pause Button on Aging Skin: OS-01 BOD...
What Causes Dark Circles Under and Around Your Eyes?
What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
lip treatment
Lip Balm Ingredients: What to Look for and What to...
earth
Exploring Blue Zones: How Can We Optimize Our Heal...
Lips
Nurturing Your Lips: How to Keep Them Moisturized ...
Lips
Uncovering the 9 Causes of Dry Lips: Why Do Lips G...
How to Travel with Skin Care
How to Travel with Skin Care Products
Why is my Skin Peeling on My Face?
SHIELD on arm
The Importance of Sunscreen: Why Should You Wear I...
Lip sunscreen
Lip Sunscreen: Do Lips Need SPF Protection?
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The Science of Gratitude
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Removing Sunscreen: Tips for Clean and Healthy Ski...
freckled skin
Skin Explained: Is Skin An Organ?
UV Light and Skin
UV Light and Skin: Effects and Protection Strategi...
What is Epidermis
Understanding The Epidermis: Functions, Compositio...
Diving into dermis
Diving into Dermis: Functions and Significance
Why Do We Get Wrinkles
Unlocking the Science of Wrinkles: Causes, Formati...
PREP enhances the effects of OS-01 FACE, and the p...
Back skin
Why Skin Barrier is Important
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Ingredient Spotlight: Bentonite Uses, Benefits, & ...
hypodermis function
Hypodermis: Exploring Its Vital Functions
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The EU is Limiting Retinol in Skincare: Here’s Eve...
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Why You Should Use OS-01 FACE & OS-01 SHIELD Toget...
Ceramides For Skin: Everything You Need to Know ne...
Age Gracefully: How to Manage Neck Wrinkles and Ac...
Discover Why Our New SPF Outperforms the Rest
How to Preserve Your Feet
How to Preserve Your Feet: 5 Strategies for Wrinkl...
Hands and Dermal Elasticity: Understanding and Man...
The Lip Lineage
The Lip Lineage: Exploring the Why Behind Wrinkled...
How to Address Stomach Wrinkles
How to Address Stomach Wrinkles For Smoother Skin
How to Get Rid of Wrinkly Skin on Arms
A Scientific Approach to Addressing Wrinkly Skin o...
What is Skin Cycling
What is Skin Cycling? Understanding, Embracing, an...
How to Skin Cycle: A Guide to Optimize Your Skin C...
Do You Know What Clinical Claims Really Mean?
What is Tinted Sunscreen?
What is Tinted Sunscreen?
two types of face wrinkles
2 Types of Wrinkles and Tips for Treating Them
Marionette Lines
Understanding Marionette Lines: Causes and Prevent...
How to Help Your Skin Act Younger
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The Science of Sunscreen: Understanding the Optima...
Better Elasticity, More Firmness: Discover OS-01 E...
Symptoms and Causes of Melasma on Face
How to Prevent Skin Aging Before It Starts
Thick Skin vs Thin Skin
A Comprehensive Guide to Understanding the Differe...
How to Strengthen Your Skin
How to Strengthen Your Skin: A Guide to Thicker, H...
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An In-Depth Look at Glycerin: What is it and What ...
Glycerin Benefits for Skin
Exploring the Benefits of Glycerin for Skin Health
Difference Between Hydrating and Moisturizing
Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
Scientific Breakthrough: OneSkin’s scientists show...
Dry Skin 101: How To Identify This Skin Type
How OS-01 Can Help Your Collagen Levels As You Age...
Developing a Skin Care Routine for Normal Skin: 4 ...
What is Normal Skin & Do I Have This Skin Type?
Skin Care Routine for Oily Skin
A Step-by-Step Guide to Creating the Perfect Skin ...
Understanding Oily Skin: Causes & Characteristics
Menopause and Skin Changes
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
Perfect Skin Care Routine for Combination Skin
4 Steps to Crafting the Perfect Skin Care Routine ...
Managing Combination Skin
A Comprehensive Guide to Understanding and Managin...
Benefits Of Moringa Oil
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
Restoring Dry Skin Around The Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
Woman washing her face
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks Of Aging - One Skin Technologies
Hallmarks of Aging
What Is Sensitive Skin
What is Sensitive Skin?
How OS-01 Works on Mature Skin
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
Dry, flaky skin
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin
What is the Best Skin Care Regimen for Aging Skin?
6 Benefits of Jojoba Oil
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
What are the Benefits of Sulforaphane?
What are the Benefits of Sulforaphane?
8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture Types
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure For Long-Term Skin Health?
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Clean Beauty: What “clean” really means and why “s...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
5 Common Perimenopause Skin Problems
Five Common Skin Problems Experienced in Perimenop...
Get to Know OneSkin’s Topical Supplements:

OS-

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The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Optimize Your Health
How to Use Peptides In Your Skincare Regimen to Op...
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Peptides vs Retinol: Is One Better For Increasing ...
body skin
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Your Body Care Routine
Three Ways To Extend Your Skinspan Starting With Y...
free radicals
What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Longevity
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening
101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
Skin Tightening Ingredients
3 Skin Tightening Ingredients To Help Boost Skin H...
How to Reduce Skin Inflammation
How to Reduce Skin Inflammation & Redness
Niacinamide
Niacinamide Vs Retinol: How Do They Compare?
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Why Is Nutrient Absorption Key To Better Skin Heal...
Dr. David Sinclair
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The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
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Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barrier
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care and Longevity
Representation of the Black Community in Skin Care...
Portrait of OneSkin Founders
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
What Is Senescence & Its Relationship To Aging?
Winter Skincare - How To Prevent Dry Skin this Sea...
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Health Is The New Wealth - One Skin Technologies
Health Is The New Wealth
Sleep: Nature’s Restart Button? - One Skin Technologies
The Correlation Between Sleep and Skin: Why It Mat...
How Relationships, Community, & Social Interaction...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging - One Skin Technologies
Healthspan: A New Way To Think About Aging